Neuronal surface antibodies in HIV-infected patients with isolated psychosis
| Autor: | LLuïsa Mestre, Francesca Canellas, Maria Inés Barceló, Susana Arboleya, Vanesa Cunill, Maria Rosa Julià, Maria Leyes, Antonio Clemente, Antoni Campins, Patricia Herbera, Maria de los Reyes Jiménez |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Psychosis Immunology Human immunodeficiency virus (HIV) HIV Infections Nerve Tissue Proteins Transfection medicine.disease_cause Antibodies Cohort Studies 03 medical and health sciences 0302 clinical medicine medicine Retrospective analysis Humans Immunology and Allergy Hiv infected patients 030212 general & internal medicine Prospective cohort study Neurons Autoimmune encephalitis biology business.industry Membrane Proteins Middle Aged medicine.disease HEK293 Cells Psychotic Disorders Neurology biology.protein Female Neurology (clinical) Antibody business 030217 neurology & neurosurgery Encephalitis |
| Zdroj: | Journal of Neuroimmunology. 301:49-52 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2016.10.008 |
| Popis: | Neuronal surface antibodies (NSA) involved in autoimmune encephalitis (AE) have been related to relapses in HVS encephalitis. Their role in non-encephalitic psychosis is controversial. We previously reported an HIV-infected patient, NSA-positive, only presenting psychosis. Therefore, we determined the NSA prevalence in a prospective cohort of 22 HIV-positive patients with psychosis and we analyzed the frequency of HIV infection among NSA tested patients due to AE suspicion. We found no NSA in the prospective cohort. In the retrospective analysis, 22% of NSA-positive versus 4.6% of negative patients were HIV-positive. Wider studies are required to clarify the relationship between NSA and HIV infection. |
| Databáze: | OpenAIRE |
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