Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration
| Autor: | Maria del carmen Llavero hurtado, Felipe A. Court, Paula Diaz, Douglas J. Lamont, Thomas M. Wishart, Alejandra Catenaccio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Proteomics Cancer Research Wallerian degeneration In silico Immunology Quantitative proteomics Biology Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience Cyclophilins Mice Contractile Proteins Ganglia Spinal medicine Animals Axon Cells Cultured Myelin Sheath Mice Knockout rho-Associated Kinases Regeneration (biology) Cell Biology Cell Dedifferentiation Functional recovery medicine.disease Sciatic Nerve Axons Molecular analysis Rats Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system Dactinomycin Original Article RNA Interference Wallerian Degeneration Neuroscience Neuroglia Cyclophilin D Axon degeneration |
| Zdroj: | Cell Death & Disease Cell death and Disease Artículos CONICYT CONICYT Chile instacron:CONICYT Catenaccio, A, Llavero hurtado, M D C, Diaz, P, Lamont, D J, Wishart, T & Court, F A 2017, ' Molecular analysis of Axonal-Intrinsic and Glial-Associated co-regulation of Axon Degeneration ', Cell Death and Disease, vol. 8, no. 11, e3166 . https://doi.org/10.1038/cddis.2017.489 |
| ISSN: | 2041-4889 |
| Popis: | Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction. |
| Databáze: | OpenAIRE |
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