Juvenile Parkinson's disease and its response to L-dopa therapy
| Autor: | Z. Braun, O. Keren, J. J. M. Askenasy, L. Mendelson |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Juvenile parkinson's disease Levodopa Neurology Adolescent Disease Internal medicine medicine Juvenile Humans Biological Psychiatry General Neuroscience Cogwheel Rigidity Parkinson Disease nervous system diseases Pedigree Psychiatry and Mental health Endocrinology Carbidopa Female Neurology (clinical) Psychology Foot (unit) medicine.drug |
| Zdroj: | Journal of neural transmission. Parkinson's disease and dementia section. 2(1) |
| ISSN: | 0936-3076 |
| Popis: | Four youngsters, between the ages of 13-27 years, presented dystonic foot. Two to three years following the appearance of the dystonic foot, cogwheel rigidity and tremor appeared on the dystonic foot side. Treatment with low doses of levodopa/carbidopa consistently reversed the symptoms. "On-off" phenomena appeared in the first years of treatment and persisted for the entire period of 5 to 15 years of illness. No parkinsonian signs were present when the dystonic foot appeared. Based on our observations and on a review of the literature, we conclude that responsiveness to low doses of L-dopa is the major marker of juvenile Parkinson's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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