Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration
| Autor: | Bruno D. Mattos, Thaís Maria da Mata Martins, Orlando J. Rojas, Ivanei Ferreira Pinheiro, Thalita Marcolan Valverde, João Henrique Lopes, Marcos Mariano, Alfredo M. Goes, Sébastien Livi, José Angelo Camilli, Liliane M. F. Lona, Rubia F. Gouveia, Lucas Pereira Lopes de Souza, F.V. Ferreira |
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| Přispěvatelé: | University of Campinas, Federal University of Minas Gerais, Technological Institute of Aeronautics, Bio-based Colloids and Materials, Brazilian Center for Research in Energy and Materials, Universidade Federal de Minas Gerais, Université de Lyon, Department of Bioproducts and Biosystems, Aalto-yliopisto, Aalto University |
| Rok vydání: | 2019 |
| Předmět: |
EXPRESSION
GROWTH-FACTOR Bone Regeneration Biocompatibility Cellular differentiation HYDROGELS Nanofibers 02 engineering and technology Bone healing 010402 general chemistry 01 natural sciences Bone morphogenetic protein 2 ANGIOGENESIS HUMAN OSTEOBLASTS Cell Line Nanocellulose law.invention Mice In vivo law Animals General Materials Science BIOACTIVE GLASS BIOMATERIALS Cellulose Bone regeneration RELEASE Tissue Scaffolds IONIC PRODUCTS Chemistry Skull PROLIFERATION 021001 nanoscience & nanotechnology Rats 0104 chemical sciences Bioactive glass 0210 nano-technology Cryogels Biomedical engineering |
| Zdroj: | Nanoscale |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c9nr05383b |
| Popis: | openaire: EC/H2020/788489/EU//BioELCell A major challenge exists in the preparation of scaffolds for bone regeneration, namely, achieving simultaneously bioactivity, biocompatibility, mechanical performance and simple manufacturing. Here, cellulose nanofibrils (CNF) are introduced for the preparation of scaffolds taking advantage of their biocompatibility and ability to form strong 3D porous networks from aqueous suspensions. CNF are made bioactive for bone formation through a simple and scalable strategy that achieves highly interconnected 3D networks. The resultant materials optimally combine morphological and mechanical features and facilitate hydroxyapatite formation while releasing essential ions for in vivo bone repair. The porosity and roughness of the scaffolds favor several cell functions while the ions act in the expression of genes associated with cell differentiation. Ion release is found critical to enhance the production of the bone morphogenetic protein 2 (BMP-2) from cells within the fractured area, thus accelerating the in vivo bone repair. Systemic biocompatibility indicates no negative effects on vital organs such as the liver and kidneys. The results pave the way towards a facile preparation of advanced, high performance CNF-based scaffolds for bone tissue engineering. |
| Databáze: | OpenAIRE |
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