A Comparison of Urine Dipstick Test with Spot Urine Protein-Creatinine Ratio and 24 Hour Urine Protein Excretion in Women with Hypertensive Disorders of Pregnancy

Autor: Dr. Ankita Chaudhary
Rok vydání: 2023
DOI: 10.5281/zenodo.7948563
Popis: Background: Estimation of 24hour urine protein excretion and evaluation of spot protein- creatinine ratio in a random urine sample have been standard methods for determination of protein excretion. . The urine dipstick method, a semi-quantitative method of proteinuria estimation, has long been used as a screening tool for the same purpose. The objective of this study was to assess the efficacy of dipstick as a test for measurement of proteinuria in comparison with 24 hour urinary protein collection and spot urine protein/creatinine ratio as a screening test in pregnant patients with suspected hypertensive disorder of pregnancy attending an obstetric outpatient service. Methods: 150 patients were recruited with suspected hypertensive disorders of pregnancy attending the obstetric outpatient service at our Department of Obstetrics and Gynecology and measured proteinuria in them by dipstick method, 24-hour urine protein collection and spot urine protein/creatinine ratio and calculated the degree of correlation between the first with the other two standard tests. Results: The correlation of the urine dipstick test values with the 24-hour urine protein excretion was strong (r=0.757),but when compared to the spot urine protein-creatinine ratio, it was moderate (r=0.612). At 1+ grading of proteinuria, urine dipstick demonstrated greater sensitivity but at 2+ grading, dipstick was more specific in identification of significant proteinuria. Conclusion: We conclude that dipstick as a test correlates better with 24 hour urine protein estimation than with the protein-creatinine ratio. Further, 1+ grading of urine dipstick could be a good screening tool for identifying proteinuria in patients attending the obstetrics outpatient service. However, the 2 + grading of the urine dipstick would be required to serve as an alternative to the 24-hour urine collection for detection of significant proteinuria or calculation of spot urine P/C ratio.
Databáze: OpenAIRE
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