Removal of blood amyloid-β with hemodialysis reduced brain amyloid-β, confirmed by brain imaging: a case report
| Autor: | Kyoko Hirano, Kazunori Kawaguchi, Yukio Yuzawa, Midori Hasegawa, Takashi Kato, Kengo Ito, Kiyoshi Fujita, Hajime Takechi, Kaori Iwata, Nobuya Kitaguchi, Shinji Matsunaga |
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| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty Amyloid β medicine.medical_treatment 030232 urology & nephrology Blood purification Case Report amyloid-β Extracorporeal 03 medical and health sciences 0302 clinical medicine Neuroimaging medicine Pathological Aβ business.industry extracorporeal blood Aβ removal system blood purification Male patient blood Aβ removal PiB/PET Hemodialysis Remove blood business Alzheimer’s disease 030217 neurology & neurosurgery E-BARS |
| Zdroj: | Neuropsychiatric Disease and Treatment |
| ISSN: | 1178-2021 |
| DOI: | 10.2147/ndt.s186118 |
| Popis: | The accumulation of amyloid-β protein (Aβ) in the brain signifies a major pathological change of Alzheimer’s disease (AD). Extracorporeal blood Aβ removal system (E-BARS) has been under development as a tool for enhancing the clearance of Aβ from the brain. Previously, we revealed that dialyzers remove blood Aβs effectively, evoking substantial Aβ influx into the blood during hemodialysis sessions as one form of blood Aβ removal by E-BARS, and that postmortem brains of hemodialysis patients exhibited lower Aβ accumulation. Here, we present a case report of a 77-year-old male patient with end-stage renal failure whose Aβ accumulation in the brain declined by initiating and continuing hemodialysis for 6 months. This report suggests that blood Aβ removal by E-BARS could be an effective therapeutic method for AD. |
| Databáze: | OpenAIRE |
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