Assessment of Optic Pathway Structure and Function in Patients With Compression of the Optic Chiasm: A Correlation With Optical Coherence Tomography
| Autor: | Pramit M. Phal, Chris Kokkinos, Helen V. Danesh-Meyer, Yuval Z. Sufaro, Christopher Steward, Patricia Desmond, Andrew D. Nichols, Bradford A. Moffat, Andrew H. Kaye |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures Nerve fiber layer Optic chiasm 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Ophthalmology Optic Nerve Diseases medicine Humans Medical physics Longitudinal Studies medicine.diagnostic_test business.industry Nerve Compression Syndromes Optic Nerve Decompression Surgical Magnetic Resonance Imaging eye diseases Visual field medicine.anatomical_structure Case-Control Studies Optic Chiasm 030221 ophthalmology & optometry Optic nerve Visual Fields medicine.symptom business Tomography Optical Coherence 030217 neurology & neurosurgery Diffusion MRI Tractography |
| Zdroj: | Investigative Opthalmology & Visual Science. 57:3884 |
| ISSN: | 1552-5783 |
| DOI: | 10.1167/iovs.15-18734 |
| Popis: | Purpose The purpose of this study was to investigate correlations between retinal fiber thickness measured by optical coherence tomography (OCT) and anterograde functional and structural differences in the optic pathway of patients with compression of the optic chiasm. Our hypothesis was that loss of visual acuity caused by chronic compressive pathologies may lead to an irreversible decline in vision because of permanent neurodegeneration of the optic radiations and visual cortex. Methods Quantitative OCT, functional magnetic resonance imaging (MRI) and diffusion tensor MRI measurements were made in 17 patients being surgically treated for chiasmal compression. Results In our study we found that surgically irreversible visual field defects and reduced retinal nerve fiber layer thickness were significantly associated with lower fractional diffusion anisotropy and higher diffusivities in optic radiations and less functional MRI activation in the visual cortex. Conclusions Damage to the retinal nerve fiber layer is associated with downstream structural and functional degradation of the optic pathway. This may be related to trans-synaptic degeneration and the fact that these factors are important potential imaging biomarkers for predicting visual recovery after surgical decompression. |
| Databáze: | OpenAIRE |
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