Comparative study of intravenous thrombolysis with rt-PA and urokinase for patients with acute cerebral infarction
| Autor: | Xu-Dong Qian, Yan-Juan Mi, Hui-Xiao Fu, Jia-Jia Li, Liang Zhao, Ya-Jun Hu, Hai-Peng Qiu, Zhi-Jie Dou, Heng Liu, Zheng Ma, Shuo Zhang, Yan-Jun Gao, Ling-Ling Kang, Fan Sun, Yun-Bo Zhu, Xiao-Xuan Zhang, Jian Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Medicine (General) medicine.medical_treatment Infarction urokinase 030204 cardiovascular system & hematology Biochemistry 0302 clinical medicine Acute cerebral infarction cerebral haemorrhage Thrombolytic Therapy Cerebral Infarction General Medicine Thrombolysis Middle Aged Recombinant Proteins acute cerebral infarction Treatment Outcome Tissue Plasminogen Activator recombinant tissue plasminogen activator Cardiology Administration Intravenous Female MMP-9 Intracranial Hemorrhages medicine.drug Adult medicine.medical_specialty Poor prognosis Intravenous thrombolysis 03 medical and health sciences R5-920 Internal medicine medicine Humans cardiovascular diseases Recombinant tissue plasminogen activator Aged Retrospective Studies Urokinase business.industry Biochemistry (medical) Cell Biology medicine.disease Urokinase-Type Plasminogen Activator United Kingdom business Biomarkers 030217 neurology & neurosurgery Retrospective Clinical Research Report |
| Zdroj: | Journal of International Medical Research, Vol 48 (2020) The Journal of International Medical Research |
| ISSN: | 1473-2300 |
| Popis: | Objective Cerebral infarction has a poor prognosis and causes a serious burden on families and society. Recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are commonly used thrombolytic agents in the clinic. However, direct and powerful clinical trial evidence to determine the therapeutic effect of rt-PA and UK on intravenous thrombolysis is lacking. Methods In this study, 180 patients with acute cerebral infarction were treated with rt-PA or UK. The National Institutes of Health Stroke Scale (NIHSS) scores, Barthel index, bleeding complications, and biomarkers were evaluated. Results No significant differences in NIHSS or Barthel scores were found between the groups. However, UK increased the risk of intracranial haemorrhage compared with rt-PA. rt-PA had increased activity in reducing serum levels of MMP-9 than UK. Conclusion Intravenous thrombolysis with rt-PA and UK in the time window of acute cerebral infarction can achieve similar therapeutic effects, but rt-PA can further reduce the risk of cerebral haemorrhage and is relatively safer than UK. |
| Databáze: | OpenAIRE |
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