Comparison of two devices for automated oxygen control in preterm infants: a randomised crossover trial

Autor: Steffen Pauws, Timothy J. Gale, Sophie J E Cramer, Hylke H. Salverda, Peter A. Dargaville, Ruben S G M Witlox, Arjan B. te Pas
Přispěvatelé: Tilburg Center for Cognition and Communication
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Ventilators
chemistry.chemical_element
Artificial/adverse effects
Target range
Oxygen
neonatology
03 medical and health sciences
0302 clinical medicine
Newborn/blood
030225 pediatrics
medicine
Humans
030212 general & internal medicine
Neonatology
Hypoxia
Premature
Oxygen saturation (medicine)
Original Research
Respiratory Distress Syndrome
Newborn
Respiratory Distress Syndrome
Newborn/blood
Respiratory Distress Syndrome
Ventilators
Mechanical
Cross-Over Studies
business.industry
Hypoxia/etiology
Respiration
Significant difference
Infant
Newborn
Obstetrics and Gynecology
Gestational age
Infant
General Medicine
Respiration
Artificial/adverse effects
Newborn
Mechanical
Crossover study
Respiration
Artificial
chemistry
Oxygen Saturation
Anesthesia
Pediatrics
Perinatology and Child Health
technology
Gestation
business
Infant
Premature
Algorithms
Zdroj: Archives of Disease in Childhood. Fetal and Neonatal Edition, 107, 20-25. BMJ PUBLISHING GROUP
Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(1), F20-F25. BMJ Publishing Group
Archives of Disease in Childhood. Fetal and Neonatal Edition
ISSN: 1359-2998
Popis: ObjectiveTo compare the effect of two different automated oxygen control devices on target range (TR) time and occurrence of hypoxaemic and hyperoxaemic episodes.DesignRandomised cross-over study.SettingTertiary level neonatal unit in the Netherlands.PatientsPreterm infants (n=15) born between 24+0 and 29+6 days of gestation, receiving invasive or non-invasive respiratory support with oxygen saturation (SpO2) TR of 91%–95%. Median gestational age 26 weeks and 4 days (IQR 25 weeks 3 days–27 weeks 6 days) and postnatal age 19 (IQR 17–24) days.InterventionsInspired oxygen concentration was titrated by the OxyGenie controller (SLE6000 ventilator) and the CLiO2 controller (AVEA ventilator) for 24 hours each, in a random sequence, with the respiratory support mode kept constant.Main outcome measuresTime spent within set SpO2 TR (91%–95% with supplemental oxygen and 91%–100% without supplemental oxygen).ResultsTime spent within the SpO2 TR was higher during OxyGenie control (80.2 (72.6–82.4)% vs 68.5 (56.7–79.3)%, p2 2 deviations occurred less frequently during OxyGenie control.ConclusionsThe OxyGenie control algorithm was more effective in keeping the oxygen saturation within TR and preventing hyperoxaemia and equally effective in preventing hypoxaemia (SpO2 Trial registry numberNCT03877198
Databáze: OpenAIRE
Externí odkaz: