Effects of differenta mitomycin C concentrations on laser-assisted subepithelial keratectomy
| Autor: | Jianlong Xu, Meng Guo, Yaoxin Yuan, Jianjiang Shi, Suxia Zhao |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
medicine.medical_specialty Visual acuity genetic structures business.industry medicine.medical_treatment Mitomycin C General Medicine Articles Ablation Laser assisted eye diseases Surgery haze medicine.anatomical_structure Immunology and Microbiology (miscellaneous) Cornea medicine laser-assisted subepithelial keratectomy mytomycin C sense organs medicine.symptom Corneal endothelial cell density business Dioptre |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-0981 |
| Popis: | The aim of the present study was to determine the effect of different concentrations of mitomycin C (MMC) administered intraoperatively during laser-assisted subepithelial keratectomy (LASEK) surgery. A total of 261 patients (496 eyes) were randomly divided into two groups: 0.04% MMC treatment group consisting of 133 patients (245 eyes) and the 0.02% MMC treatment group consisting of 128 patients (251 eyes). The MMC solutions were dropped intraoperatively onto the ablation region and the duration was dependent on the preoperative refractive power of the patient’s cornea: ≤−3.00 diopters (D), 30 sec; between −3.25 D and −6.00 D, 60 sec; between −6.25 D and −9.00 D, 90 sec and ≥−9.25 D, 110 sec. Postoperative observations included haze formation, visual acuity, changes in refractive power, corneal endothelial cell density and incidence of complications. The one year postoperative incidence of haze differed significantly between the groups (P0.05). Thus, the intraoperative application of 0.04% MMC solution effectively inhibited haze formation and markedly improved the efficacy of LASEK surgery, when compared with that of 0.02% MMC. |
| Databáze: | OpenAIRE |
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