Comparison of the QuantiFERON-TB and tuberculin skin test for detection of latent tuberculosis infection in cancer patients in a developing country
| Autor: | Alfredo Saavedra, Aylen Vanessa Ospina-Serrano, David A. Suarez-Zamora, Adriana Catalina Galeano, Ana Milena Callejas, Mónica Patricia Caicedo-Verástegui, Javier Leonardo Galindo, Plutarco García-Herreros, Luis Gerardo García-Herreros, Margarita Baldión, Darío Londoño, Diana María Palacios |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Concordance Population lcsh:Medicine Tuberculin Logistic regression QuantiFERON 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Tuberculosis 030212 general & internal medicine education education.field_of_study Latent tuberculosis Receiver operating characteristic business.industry lcsh:R Cancer Original Articles bacterial infections and mycoses medicine.disease 030228 respiratory system business |
| Zdroj: | ERJ Open Research, Vol 5, Iss 4 (2019) ERJ Open Research |
| ISSN: | 2312-0541 |
| DOI: | 10.1183/23120541.00258-2018 |
| Popis: | Cancer patients have an increased risk of reactivation of latent tuberculosis infection. It is unknown which strategy on screening should be used in this population in developing countries. We aimed to determine the concordance between the tuberculin skin test (TST) and QuantiFERON®-TB (QFT) assay in order to diagnose latent tuberculosis infection in cancer patients. We conducted a cross-sectional study of the agreement of diagnostic tests. Prevalence and agreement between tests were calculated. A logistic regression to assess predictors of discordance was performed. The accuracy of the TST to predict QFT results by a receiver operating characteristic (ROC) curve was evaluated. We included 149 adults with cancer without active tuberculosis. Prevalence of latent tuberculosis infection was 21.5% (n=32), defined as positive results on either test. Test agreement was moderate for the diagnosis of latent tuberculosis infection (κ=0.43, 90% CI 0.26–0.6). No predictor was associated with the chance of discordant results. Agreement improved slightly using a cut-off point ≥8 mm (κ=0.5, 90% CI 0.35–0.66). In a moderate-incidence setting, a moderate agreement was found between tests in cancer patients. Modification of the cut-off points of test results achieved marginally better agreement between the TST and QFT. QuantiFERON and tuberculin skin test have a moderate agreement for latent tuberculosis infection diagnosis in cancer patients. Modifying cut-off points may improve agreement of tests. http://bit.ly/32bNwLc |
| Databáze: | OpenAIRE |
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