Immunosuppression effects of bone marrow mesenchymal stem cells on renal interstitial injury in rats with unilateral ureteral obstruction
Autor: | Ying-Deng Wang, Jun-Yan Fang, Wei Su, Ying-Li Liu, Shu-Li Xian, Wei Zhang, Feng Zhuang |
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Rok vydání: | 2012 |
Předmět: |
CD4-Positive T-Lymphocytes
Male Pathology medicine.medical_specialty medicine.medical_treatment Immunology Population Cell Inflammation urologic and male genital diseases Kidney stomatognathic system Fibrosis Bone Marrow Medicine Animals Interferon gamma IL-2 receptor Rats Wistar education Cells Cultured education.field_of_study business.industry FOXP3 hemic and immune systems Immunosuppression Forkhead Transcription Factors Mesenchymal Stem Cells Ectodysplasins medicine.disease Rats medicine.anatomical_structure medicine.symptom business medicine.drug Ureteral Obstruction |
Zdroj: | Cellular immunology. 276(1-2) |
ISSN: | 1090-2163 |
Popis: | We investigated the effects of intravenously administered bone marrow mesenchymal stem cells (BMSCs) on renal interstitial inflammation and fibrosis. In unilateral ureteral obstruction (UUO) rats, the CD4(+)CD25(+) regulatory T-cell (Treg) cell, macrophage population and some inflammation related cytokines were tested. In the BMSCs -treated rats, renal exhibited lower renal Masson scores, decreased macrophage infiltration and interferon gamma (IFNγ) expression, and increased forkhead transcription factor (Foxp3) and interleukin-10 (IL-10) expression. No significant differences in the CD4(+)CD25(+) Treg population and renal transforming growth factor-β1 (TGFβ1) expression were observed between BMSCs-treated group and control group (p>0.05). In conclusion, BMSCs infusion leads to an anti-inflammation response in the early stage of UUO which may related to paracine mechanism. |
Databáze: | OpenAIRE |
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