Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties
| Autor: | Igor Bdikin, Ivonne Rosales, Daniel Luna, Laura Salazar, Brian J. Rodriguez, Alejandro Heredia, Alicia Negrón |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Amyloid Materials science biology Amyloid beta Piezoelectricity Nanotechnology 04 agricultural and veterinary sciences Self-assembly 03 medical and health sciences Psychiatry and Mental health chemistry.chemical_compound chemistry 040102 fisheries biology.protein Neurodegenerative disorders 0401 agriculture forestry and fisheries Piezoelectric biosensor Diphenylalanine 030304 developmental biology |
| Popis: | Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process can hinder the biological stability and give rise to the formation of amyloid structures associated with neurodegenerative diseases; 2) investigations in this field may lead to an improved understanding of high-performance, functional biological nanomaterials, 3) new technologies could be established based on peptide self-assembly and the resultant functional properties, e.g., in the creation of a piezoelectric device formed with vertical diphenylalanine peptide tubes as a piezoelectric biosensor, and 4) new knowledge can be generated about neurodegenerative disorders, potentially yielding new therapies. Therefore, in this review, we will present the current investigations associated with self-assembly of amyloid-beta, the mechanisms that generate new structures, as well as theoretical calculations exploring the functionality of the structures under physiological pressure and electric field. Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica |
| Databáze: | OpenAIRE |
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