Oral contraceptive use and risk of benign breast disease in a French case-control study of young women
| Autor: | Charreau I, Guinebretiére Jm, Bachelot A, Plu-Bureau G, Contesso G, Lê Mg |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Time Factors Epidemiology Sexual Behavior Breast Diseases Breast cancer Pregnancy Risk Factors Humans Medicine Thyroid Neoplasms Risk factor Family history skin and connective tissue diseases Menarche Gynecology business.industry Obstetrics Public Health Environmental and Occupational Health Case-control study Confounding Factors Epidemiologic Odds ratio medicine.disease Oncology Case-Control Studies Female France Breast disease business Contraceptives Oral |
| Zdroj: | European Journal of Cancer Prevention. 2:147-154 |
| ISSN: | 0959-8278 |
| Popis: | We report the results of a French hospital-based case-control study designed to analyse the relation between the use of oral contraceptives (OC) and the risk of benign breast disease (BBD). The cases were 286 women, each less than 46 years old, with BBD histologically verified between 1982 and 1985. Controls were 382 patients, matched to cases on year of birth and month of interview, and who were hospitalized for a non-malignant disease other than BBD. Odds ratios were estimated by multivariate regression, taking into account level of education, place of residence, family history of breast cancer, age at menarche, number of children, age at first full-term pregnancy and Quetelet index. The risk of BBD was found to decrease significantly with a longer use of OC before the first full-term pregnancy (FFTP), but there was no association between the risk of BBD and the duration of OC use after FFTP. OC use before FFTP reduced the risk of non-proliferative disease, but did not significantly affect the risk of proliferative disease. These results did not depend on the amount of oestrogen (0.05 mg or more vs0.05 mg) contained in OC.This article reports the findings of a French-based case-control study examining the relationship between risk of benign breast disease (BBD) and oral contraceptive (OC) use. Special emphasis was given to duration of OC use before and after the first full-term pregnancy (FFTP). Conditional multivariate logistic regression was the statistical process used to analyze the findings. 286 women with verified BBD were studied. 382 women, who were hospitalized for a non-BBD disease, were used as controls. Each case was matched with at least one control. 7 confounders were adjusted for. Confounders included family history of breast cancer, level of education, place of residence, age at menarche, number of children, age at FFTP, and Quetelet index. The risk of BBD decreased with longer OC use before the FFTP. There was no association observed between risk of developing BBD and the duration of OC use after the FFTP. OC use before the FFTP reduced the risk of non-proliferative disease, but did not significantly affect the risk of proliferative disease. |
| Databáze: | OpenAIRE |
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