Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK
| Autor: | Chris Griffiths, Richard Hooper, Aklak Choudhury, Claire L. Greiller, Christopher Corrigan, David A. Jolliffe, Wai Yee James, Elina Hyppönen, Angshu Bhowmik, David E. Simcock, Kamrul Islam, Peter Timms, Neil Barnes, Raj K Rajakulasingam, Robert Walton, Adrian R. Martineau |
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| Přispěvatelé: | Jolliffe, David A, James, Wai Yee, Hooper, Richard L, Barnes, Neil C, Greiller, Claire L, Islam, Kamrul, Bhowmik, Angshu, Timms, Peter M, Rajakulasingam, Raj K, Choudhury, Aklak B, Simcock, David E, Hyppönen, Elina, Walton, Robert T, Corrigan, Christopher J, Griffiths, Christopher J, Martineau, Adrian R, 5th International Conference on Vitamin D Deficiency, Nutrition and Human Health Abu Dhabi, U Arab Emirates 24-25 March 2016 |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Vital capacity Neutrophils Endocrinology Diabetes and Metabolism Clinical Biochemistry spirometry vitamin D Biochemistry Gastroenterology Calcitriol receptor Severity of Illness Index Body Mass Index FEV1 Pulmonary Disease Chronic Obstructive 0302 clinical medicine Endocrinology Cytochrome P-450 Enzyme System single nucleotide polymorphism London Prevalence 030212 general & internal medicine Vitamin D Aged 80 and over COPD medicine.diagnostic_test Continental Population Groups Middle Aged Respiratory Function Tests DNA-Binding Proteins Low Density Lipoprotein Receptor-Related Protein-2 Molecular Medicine Female medicine.symptom Spirometry Adult medicine.medical_specialty Oxidoreductases Acting on CH-CH Group Donors Receptors Cell Surface vitamin D deficiency 03 medical and health sciences FEV1/FVC ratio Endocrinology & Metabolism Internal medicine medicine Vitamin D and neurology Humans Molecular Biology Aged business.industry Racial Groups 0601 Biochemistry And Cell Biology Cell Biology medicine.disease Vitamin D Deficiency FVC respiratory tract diseases Single nucleotide polymorphism Eosinophils Cross-Sectional Studies 030228 respiratory system Gene Expression Regulation Immunology Sputum Receptors Calcitriol business Transcription Factors |
| Zdroj: | Jolliffe, D A, James, W Y, Hooper, R L, Barnes, N C, Greiller, C L, Islam, K, Bhowmik, A, Timms, P M, Rajakulasingam, R K, Choudhury, A B, Simcock, D E, Hyppönen, E, Walton, R T, Corrigan, C J, Griffiths, C J & Martineau, A R 2017, ' Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK ', Journal of Steroid Biochemistry and Molecular Biology . https://doi.org/10.1016/j.jsbmb.2017.01.019 |
| DOI: | 10.1016/j.jsbmb.2017.01.019 |
| Popis: | Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), yet a comprehensive analysis of environmental and genetic determinants of serum 25-hydroxyvitamin D (25[OH]D) concentration in patients with this condition is lacking. We conducted a multi-centre cross-sectional study in 278 COPD patients aged 41–92 years in London, UK. Details of potential environmental determinants of vitamin D status and COPD symptom control and severity were collected by questionnaire, and blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction. All participants perform ed spirometry and underwent measurement of weight and height. Quadriceps muscle strength (QS) was measured in 134 participants, and sputum induction with enumeration of lower airway eosinophil and neutrophil counts was performed for 44 participants. Thirty-seven single nucleotide polymorphisms (SNP) in 11 genes in the vitamin D pathway (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, CYP27A1, CYP3A4, LRP2, CUBN, RXRA, and VDR) were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration and to determine whether vitamin D status or genetic factors independently associated with % predicted forced expiratory volume in one second (FEV 1 ), % predicted forced vital capacity (FVC), the ratio of FEV 1 to FVC (FEV 1 :FVC), daily inhaled corticosteroid (ICS) dose, respiratory quality of life (QoL), QS, and the percentage of eosinophils and neutrophils in induced sputum. Mean serum 25(OH)D concentration was 45.4 nmol/L (SD 25.3); 171/278 (61.5%) participants were vitamin D deficient (serum 25[OH]D concentration < 50 nmol/L). Lower vitamin D status was independently associated with higher body mass index (P = 0.001), lower socio-economic position (P = 0.037), lack of vitamin D supplement consumption (P < 0.001), sampling in Winter or Spring (P for trend = 0.006) and lack of a recent sunny holiday (P = 0.002). Vitamin D deficiency associated with reduced % predicted FEV 1 (P for trend = 0.060) and % predicted FVC (P for trend = 0.003), but it did not associate with FEV 1 :FVC, ICS dose, QoL, QS, or the percentage of eosinophils or neutrophils in induced sputum. After correction for multiple comparisons testing, genetic variation in the vitamin D pathway was not found to associate with serum 25(OH)D concentration or clinical correlates of COPD severity. Vitamin D deficiency was common in this group of COPD patients in the UK, and it associated independently with reduced % predicted FEV1 and FVC. However, genetic variation in the vitamin D pathway was not associated with vitamin D status or severity of COPD. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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