Cellular Membrane Microparticles: Potential Targets of Combinational Therapy for Vascular Disease
| Autor: | Yingxia Liu, Ji C. Bihl, Yanfang Chen, Xiang Xiao, Ran Fan, Langni Liu, Bin Zhao, Xiaotang Ma, Jinju Wang, Kexia Bi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Blood Platelets
Pathology medicine.medical_specialty Cellular membrane Cell Apoptosis Bioinformatics Severity of Illness Index Cell-Derived Microparticles medicine Animals Humans Membrane vesicle Molecular Targeted Therapy Vascular Diseases Pharmacology Vascular disease business.industry medicine.disease Combined Modality Therapy medicine.anatomical_structure Membrane protein Potential biomarkers Endothelium Vascular Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Current Vascular Pharmacology. 13:449-458 |
| ISSN: | 1570-1611 |
| DOI: | 10.2174/1570161112666141014145440 |
| Popis: | Vascular disease constitutes the leading health problem throughout the entire world. Current therapies for vascular disease mainly rely on comprehensive strategies including control of risk factors, vascular interventions and conventional supportive treatments. To improve the preventive and therapeutic efficacies of current approaches, novel combinational therapies are required. Microparticles (MPs) are small membrane vesicles derived from cells undergoing stress, activation or apoptosis. They carry the characteristics of their parent cells, enabling them to serve as potential biomarkers for various diseases. Of note, MPs also have been shown to mediate cell communications through transferring membrane proteins, phospholipids and RNAs from their parent cells to recipient cells. Recent novel approaches have started to reveal the functions of MPs. In this review, we summarize the general concepts and the latest research progress in MPs. And the potential of MPs as novel targets of combinational therapy for vascular disease will be discussed. |
| Databáze: | OpenAIRE |
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