S100 and Pan-Trk Staining to Report NTRK Fusion-Positive Uterine Sarcoma: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual Meeting
| Autor: | Sarah Chiang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Pathology medicine.medical_specialty CD34 Cervix Uteri Sensitivity and Specificity Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine Biomarkers Tumor Humans Receptor trkC Nuclear atypia Receptor trkA In Situ Hybridization Fluorescence Uterine sarcoma medicine.diagnostic_test business.industry S100 Proteins Obstetrics and Gynecology Soft Tissue Fibrosarcoma High-Throughput Nucleotide Sequencing Sarcoma Middle Aged medicine.disease Immunohistochemistry 030104 developmental biology Premenopause 030220 oncology & carcinogenesis Trk receptor Uterine Neoplasms Desmin Female Gene Fusion business Fluorescence in situ hybridization |
| Zdroj: | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 40(1) |
| ISSN: | 1538-7151 |
| Popis: | NTRK fusion-positive uterine sarcoma is a recently recognized mesenchymal tumor that is defined by its morphologic resemblance to soft tissue fibrosarcoma, NTRK gene rearrangements, and potential response to Trk inhibition. Reported lesions affect premenopausal women with a median age of 32 yr, and most arise in the uterine cervix. Haphazard, storiform, or herringbone patterns of spindle cells with mild to moderate nuclear atypia are characteristic. SMA, CD34, and S100 are variably positive, but tumors are negative for desmin, ER, PR, and SOX10 and retain H3K27me3 expression. While pan-Trk immunohistochemistry is positive in these tumors, it has decreased sensitivity and specificity in the evaluation of sarcomas in general and the detection of NTRK3 rearrangements. A variety of molecular methods such as fluorescence in situ hybridization and next-generation sequencing may be useful in confirming NTRK fusion in fibrosarcoma-like uterine sarcomas. |
| Databáze: | OpenAIRE |
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