Maternal nutrient restriction in guinea pigs as an animal model for studying growth-restricted offspring with postnatal catch-up growth
| Autor: | Brad Matushewski, Bryan S. Richardson, Evan Formosa, Catherine L. Nevin, Yohei Maki, Timothy R. H. Regnault |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Time Factors Physiology Offspring Guinea Pigs Nutritional Status Gestational Age Biology Weight Gain 03 medical and health sciences Animal model Nutrient Pregnancy Physiology (medical) Fetal growth Animals Birth Weight Caloric Restriction Fetal Growth Retardation Fetal growth restriction Age Factors Maternal Nutritional Physiological Phenomena Organ Size Maternal undernourishment Disease Models Animal 030104 developmental biology Animals Newborn Postnatal catch-up growth Animal Nutritional Physiological Phenomena Female |
| Zdroj: | Paediatrics Publications |
| ISSN: | 1522-1490 |
| Popis: | We determined the impact of moderate maternal nutrient restriction (MNR) in guinea pigs with fetal growth restriction (FGR) on offspring body and organ weights, hypothesizing that FGR-MNR animals will show catch-up growth but with organ-specific differences. Guinea pig sows were fed ad libitum (Control) or 70% of the control diet from 4 weeks preconception, switching to 90% at midpregnancy (MNR). Control newborns >95 g [appropriate for gestational age (AGA); n = 37] and MNR newborns |
| Databáze: | OpenAIRE |
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