Association of adiponectin with hepatic steatosis: a study of 1,349 subjects in a random population sample

Autor: Marion, Flechtner-Mors, Samuel N, George, Suemeyra, Oeztuerk, Mark M, Haenle, Wolfgang, Koenig, Armin, Imhof, Bernhard O, Boehm, Tilmann, Graeter, Richard A, Mason, Wolfgang, Kratzer, Atilla S, Akinli, S, Wolff
Rok vydání: 2014
Předmět:
Male
Comorbidity
Body Mass Index
chemistry.chemical_compound
Non-alcoholic Fatty Liver Disease
Germany
Gamma-glutamyltransferase
Ultrasonography
Metabolic Syndrome
Medicine(all)
biology
Smoking
Fatty liver
Alanine Transaminase
gamma-Glutamyltransferase
General Medicine
Middle Aged
C-Reactive Protein
Female
Adiponectin
Research Article
Adult
medicine.medical_specialty
Adolescent
Alcohol Drinking
Adipose tissue
General Biochemistry
Genetics and Molecular Biology
Insulin resistance
NAFLD
Internal medicine
medicine
Humans
Aspartate Aminotransferases
Triglycerides
Aged
Biochemistry
Genetics and Molecular Biology(all)
Cholesterol
business.industry
Cholesterol
HDL
nutritional and metabolic diseases
Alkaline Phosphatase
medicine.disease
Cross-Sectional Studies
Endocrinology
chemistry
Alanine transaminase
biology.protein
Insulin Resistance
Metabolic syndrome
Steatosis
business
Zdroj: BMC Research Notes
ISSN: 1756-0500
DOI: 10.1186/1756-0500-7-207
Popis: Background Objective of the present study was to examine the association between adiponectin and hepatic steatosis, and other biochemical and anthropometric parameters in healthy subjects. Results A total of 1349 subjects (age 18–65 years) underwent ultrasound examination of the liver. Mean adiponectin concentration for the study collective was 11.35 ± 6.28 μg/mL. The following parameters were assessed for their association with adiponectin: body-mass index (BMI); age; sex; arterial blood pressure; nicotine use; alcohol consumption; physical activity; metabolic syndrome; total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol; triglycerides; aspartate aminotransferase (AST); alanine aminotransferase (ALT); γ-glutamyltransferase (GGT); alkaline phosphatase (AP); C-reactive protein (CRP); insulin sensitivity according to the Homeostasis Model Assessment (HOMA); random blood glucose; and the degree of steatosis of the liver. The numerical differences in the variables influencing adiponectin returned in the descriptive analysis were confirmed at bivariate analysis for BMI, ALT, AST, GGT, AP, total and HDL cholesterol, triglycerides, CRP, arterial blood pressure, metabolic syndrome, nicotine use and alcohol consumption. The logistic regression of the multivariate analysis showed that male sex, hepatic steatosis, BMI, metabolic syndrome, tobacco smoking and CRP correlate negatively with adiponectin, while age, moderate alcohol consumption and HDL cholesterol exhibit a positive association. Conclusions The results of the present study confirm the findings of previous research. Adiponectin correlates negatively with cardiometabolic risk factors and is an independent indicator for non-alcoholic fatty liver disease (NAFLD).
Databáze: OpenAIRE
Externí odkaz: