Advancing lung organoids for COVID-19 research
| Autor: | van der Vaart, Jelte, Lamers, Mart M., Haagmans, Bart L., Clevers, Hans |
|---|---|
| Přispěvatelé: | Virology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses Neuroscience (miscellaneous) Medicine (miscellaneous) Models Biological Lung/virology Pulmonary Alveoli/virology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Models Pandemic Organoid medicine Pathology Animals Humans RB1-214 Intensive care medicine Lung Pandemics COVID-19/epidemiology 030304 developmental biology 0303 health sciences SARS-CoV-2 business.industry SARS-CoV-2/pathogenicity Organoids/virology COVID-19 Biological Organoids Pulmonary Alveoli medicine.anatomical_structure Research Design Perspective Medicine Research Design/trends business 030217 neurology & neurosurgery |
| Zdroj: | Disease Models & Mechanisms, Vol 14, Iss 6 (2021) DMM Disease Models and Mechanisms, 14(6):dmm049060. Company of Biologists Ltd Disease Models & Mechanisms article-version (VoR) Version of Record |
| ISSN: | 1754-8411 1754-8403 |
| Popis: | The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. Model systems that poorly represent a virus' cellular environment, however, may impede research and waste resources. Collaborations between cell biologists and virologists have led to the rapid development of representative organoid model systems to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We believe that lung organoids, in particular, have advanced our understanding of SARS-CoV-2 pathogenesis, and have laid a foundation to study future pandemic viruses and develop effective treatments. Summary: Pulmonary organoid model systems for COVID-19 research have played a significant role in understanding SARS-CoV-2 pathogenesis and may change the way we screen for potential antivirals in the future. |
| Databáze: | OpenAIRE |
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