Hepatitis C treatment uptake and response among human immunodeficiency virus/hepatitis C virus-coinfected patients in a large integrated healthcare system
| Autor: | Daniel G. Korn, Michael J. Silverberg, Scott Chamberland, Varun Saxena, Suk I. Seo, David J. Witt, Jamila H. Champsi, Julia L. Marcus, Laura C. Gittleman, Jennifer B. Lai, Leo B. Hurley, Jennifer O Lam, Joanna Ready, Charles P. Quesenberry |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Sustained Virologic Response Hepatitis C virus Human immunodeficiency virus (HIV) HIV Infections Dermatology Hepacivirus medicine.disease_cause Medicare Antiviral Agents Article 03 medical and health sciences 0302 clinical medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Aged Retrospective Studies Insurance Health business.industry Coinfection Delivery of Health Care Integrated Public Health Environmental and Occupational Health virus diseases Hepatitis C Middle Aged medicine.disease Virology United States Infectious Diseases Treatment Outcome Socioeconomic Factors Hcv treatment 030211 gastroenterology & hepatology Female business Healthcare system |
| Zdroj: | International journal of STDAIDS. 30(7) |
| ISSN: | 1758-1052 |
| Popis: | U.S. guidelines recommend that patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) be prioritized for HCV treatment with direct-acting antiviral agents (DAAs), but the high cost of DAAs may contribute to disparities in treatment uptake and outcomes. We evaluated DAA initiation and effectiveness in HIV/HCV-coinfected patients in a U.S.-based healthcare system during October 2014–December 2017. Of 462 HIV/HCV-coinfected patients, 276 initiated DAAs (70% cumulative proportion treated over three years). Lower likelihood of DAA initiation was observed among patients with Medicare (government-sponsored insurance) versus commercial insurance (adjusted rate ratio [aRR] = 0.62, 95% CI = 0.46–0.84), patients with drug abuse diagnoses (aRR = 0.72, 95% CI = 0.54–0.97), patients with CD4 cell count |
| Databáze: | OpenAIRE |
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