Differential effect of DHEA on mitogen-induced proliferation of T and B lymphocytes
| Autor: | Yuichi Nakagawa, Takehiko Ohzeki, Yuji Sakakura |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Staphylococcus aureus Endocrinology Diabetes and Metabolism T cell T-Lymphocytes Clinical Biochemistry Immunoglobulins Biochemistry Peripheral blood mononuclear cell Endocrinology Immune system Internal medicine polycyclic compounds medicine Concanavalin A Humans Phytohemagglutinins skin and connective tissue diseases Molecular Biology B cell Cell Proliferation B-Lymphocytes biology Dose-Response Relationship Drug Adrenal gland Pokeweed mitogen Cell Biology T lymphocyte Dehydroepiandrosterone medicine.anatomical_structure Pokeweed Mitogens biology.protein Leukocytes Mononuclear Molecular Medicine Mitogens human activities hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of steroid biochemistry and molecular biology. 99(2-3) |
| ISSN: | 0960-0760 |
| Popis: | Dehydroepiandrosterone (DHEA) is the predominant steroid hormone secreted by adrenal gland, and it has been proposed in recent years that DHEA has significant effects on immune function. We investigated the effect of DHEA (1 × 10 −5 –1 × 10 −8 M) on proliferation of human T cells and B cells and on immunoglobulin production, a representative function of B cells. High doses of DHEA (1 × 10 −5 ) significantly inhibited proliferation of peripheral blood mononuclear cells (PBMCs) and T cells induced by T cell mitogens hemagglutinin (PHA) and concanavalin A (Con A). Proliferation of PBMCs induced by B cell mitogens pokeweed mitogen (PWM) was increased by 1 × 10 −7 –1 × 10 −6 M DHEA. Proliferation of PBMCs and B cells induced by Staphylococcus aureus Cowan strain I (SAC) was not significantly changed at any concentrations of DHEA. However, a concentration of 1 × 10 −7 M DHEA tended to potentiate their proliferation. This study suggested that DHEA acted on T and B lymphocytes differentially in immune system. |
| Databáze: | OpenAIRE |
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