Ethnicity and polycystic ovary syndrome are associated with independent and additive decreases in insulin action in Caribbean-Hispanic women
| Autor: | Georgette Green, Andrea Dunaif, Roberta Delson, Lynn R. Sorbara |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Adolescent Metabolic Clearance Rate medicine.medical_treatment Endocrinology Diabetes and Metabolism Biology Insulin resistance Internal medicine Sex Hormone-Binding Globulin medicine Hyperinsulinemia Internal Medicine Humans Insulin Cyst Testosterone Risk factor Pancreatic hormone Analysis of Variance Body Weight Dominican Republic Puerto Rico Androstenedione Hispanic or Latino Glucose Tolerance Test medicine.disease Polycystic ovary Lipids United States Endocrinology Clamp Body Composition Female Insulin Resistance Polycystic Ovary Syndrome |
| Zdroj: | Diabetes. 42:1462-1468 |
| ISSN: | 0012-1797 |
| DOI: | 10.2337/diabetes.42.10.1462 |
| Popis: | This study was conducted to determine the impact of polycystic ovary syndrome and ethnicity on insulin action. Thirteen Caribbean-Hispanic and 10 non-Hispanic white polycystic ovary syndrome women were compared with 5 Caribbean-Hispanic and 8 non-Hispanic white normal women matched for age, weight, and body composition. All subjects underwent a 2-h 75 g oral glucose tolerance test and euglycemic glucose clamp study with a 40 mU.m−2 · min−1 insulin dose. Hepatic glucose production was determined basally and throughout the euglycemic clamp study. Polycystic ovary syndrome was associated with significant increases in fasting insulin levels (P < 0.05) and in 2-h postglucose-load glucose and insulin levels (P < 0.001). Ethnicity was not associated with any changes in these parameters. Polycystic ovary syndrome but not ethnicity was also associated with hepatic insulin resistance, because significant (P < 0.05) residual hepatic glucose production occurred during the euglycemic clamp in the polycystic ovary syndrome women. However, significant independent effects existed for both polycystic ovary syndrome (P < 0.01) and ethnicity (P < 0.05) that resulted in decreased insulin-mediated glucose disposal. Similarly, significant independent effects of polycystic ovary syndrome (P < 0.005) and ethnicity (P < 0.05) occurred, resulting in increased steady-state insulin levels during the euglycemic clamp. This appeared to be, in part, secondary to a decrease in the metabolic clearance rate of insulin associated with ethnicity (P < 0.05). We conclude that polycystic ovary syndrome and ethnicity result in independent and additive decreases in insulin sensitivity in Caribbean-Hispanic women. Insulin resistance resulting in hyperinsulinemia may account for the increased prevalence of both polycystic ovary syndrome and of NIDDM in Caribbean-Hispanic women. |
| Databáze: | OpenAIRE |
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