Influence of left ventricular mass on left ventricular diastolic filling in normotensive morbid obesity
| Autor: | Martin A. Alpert, M. Wail Hashimi, Vaskar Mukerji, Clara V. Massey, Boyd E. Terry, Michael V. Cohen, Hercules Panayiotou, Charles R. Lambert |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Lean control medicine.medical_specialty Diastole Internal dimension Doppler echocardiography Body weight Left ventricular mass Morbid obesity Ventricular Dysfunction Left Internal medicine medicine Humans medicine.diagnostic_test business.industry Hemodynamics Middle Aged Obesity Morbid Blood pressure Echocardiography Cardiology Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Heart Journal. 130:1068-1073 |
| ISSN: | 0002-8703 |
| Popis: | To identify factors influencing left ventricular (LV) diastolic filling in patients with morbid obesity, we performed transthoracic and Doppler echocardiography on 50 subjects whose actual body weight was ≥twice their ideal body weight and on 50 normal lean control subjects. The transmitral Doppler EA ratio and E wave deceleration half-time were used to assess LV diastolic filling. Significant negative correlations were seen between the EA ratio and the LV internal dimension in diastole ( r = 0.819, p = 0.0001), systolic blood pressure ( r = 0.751, p = 0.0001), LV end-systolic wall stress ( r = 0.782, p = 0.0001), and LV mass/height index ( r = 0.901, p = 0.0001). Significant positive correlations were seen between the E wave deceleration half-time and the LV internal dimension in diastole ( r = 0.743, p = 0.0001), systolic blood pressure ( r = 0.789, p = 0.0001), LV end-systolic wall stress ( r = 0.828, p = 0.0001), and LV mass/height index ( r = 0.831, p = 0.0001). No correlation was seen between diastolic blood pressure and either index of LV diastolic filling. Thus increasing LV mass is associated with progressive impairment of LV diastolic filling in morbidly obese individuals. The aforementioned alterations in LV loading conditions may contribute to impairment of LV diastolic filling directly or by increasing LV mass. |
| Databáze: | OpenAIRE |
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