Relation of glutathione S-transferase genotypes (GSTM1 and GSTT1) to laryngeal squamous cell carcinoma risk
Autor: | Oguz Cilingir, Kayhan Öztürk, M. Hamza Muslumanoglu, Bedri Özer, M. Selman Yildirim, Hasan Acar, Tülin Çora |
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Rok vydání: | 2006 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Alcohol Drinking Genotype Population Biology Gastroenterology Gene Frequency Risk Factors Internal medicine Multiplex polymerase chain reaction Genetics medicine Humans Genetic Predisposition to Disease Neoplasm Metastasis education Laryngeal Neoplasms Molecular Biology Allele frequency Gene Aged Glutathione Transferase education.field_of_study Smoking Age Factors Case-control study Middle Aged Laryngeal squamous cell carcinoma Molecular biology Glutathione S-transferase Case-Control Studies Carcinoma Squamous Cell biology.protein |
Zdroj: | Cancer Genetics and Cytogenetics. 169:89-93 |
ISSN: | 0165-4608 |
Popis: | The purpose of the present study was to investigate GSTM1 and GSTT1 genotypes by using multiplex polymerase chain reaction (PCR) in patients with laryngeal squamous cell carcinoma (LSCC). The genotypes of 110 patients with LSCC and of 197 healthy subjects as the control group were determined by PCR analysis for GSTM1 and GSTT1 genes. Results showed that frequencies of GSTM1-null, GSTT1-null, and both GSTs-null genotypes were 51.8, 30, and 16.4%, respectively, in the patients with LSCC and 37.6, 15.7, and 5.6% in the control group. There was a significant difference between the genotype distributions of all GSTs in patients and in control groups (P < 0.05). The results support the hypothesis that null genotypes of GSTM1 and GSTT1 can reduce detoxification capacity of GSTs as members of the xenobiotic enzyme system. GSTM1-null, GSTT1-null, and both GSTs-null genotypes were more common in the patients with LSCC than in the control group. Patients with both GSTs-null genotypes had the highest risk for supraglottic LSCC in the early period, even if they were light-to-medium smokers. Investigation and determination of the genetic basis of LSCC may contribute to detection of risk groups and to prevent LSCC in the population. |
Databáze: | OpenAIRE |
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