Overexpression of FGFR3 in HPV-positive Tonsillar and Base of Tongue Cancer Is Correlated to Outcome
| Autor: | Torbjörn Ramqvist, Cinzia Bersani, Anders Näsman, Linnea Haeggblom, Linda Marklund, Ramona Gabriela Ursu, Tina Dalianis, Simona Giusca |
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| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Oncology Adult Male congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Tonsillar Neoplasms Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Growth factor receptor Tongue Internal medicine Gene expression medicine TaqMan Biomarkers Tumor Humans Receptor Fibroblast Growth Factor Type 3 Papillomaviridae Aged Aged 80 and over business.industry Squamous Cell Carcinoma of Head and Neck Papillomavirus Infections General Medicine Fibroblast growth factor receptor 3 Middle Aged musculoskeletal system Prognosis Immunohistochemistry Tongue Neoplasms stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Head and Neck Neoplasms 030220 oncology & carcinogenesis Mutation Carcinoma Squamous Cell Base of tongue cancer Female business Oncovirus |
| Zdroj: | Anticancer research. 38(8) |
| ISSN: | 1791-7530 |
| Popis: | BACKGROUND/AIM Human papillomavirus-positive (HPV+) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) have better outcome than corresponding HPV- cancers. To better individualize treatment, additional predictive markers are needed. Previously, we have shown that mutated fibroblast growth factor receptor 3 protein (FGFR3) was correlated to poorer prognosis and here FGFR3 expression was further analyzed. PATIENTS AND METHODS One-hundred-fifteen HPV+TSCC/ BOTSCC biopsies were analyzed for FGFR3 by immunohistochemistry (IHC), and 109/115 were analyzed for FGFR3 mutations by Ion Proton sequencing, or by Competitive Allele-Specific Taqman PCR (CAST-PCR). Disease-free survival (DFS) was then calculated according to FGFR3 IHC expression. RESULTS CAST-PCR was useful for detecting the three most common FGFR3 mutations. Focusing especially on the 98/115 patients with HPV+TSCC/BOTSCC and wild-type FGFR3, high FGFR3 expression correlated to significantly better 3-year DFS, p=0.043. CONCLUSION In patients with HPV+TSCC/BOTSCC and wild-type FGFR3, overexpression of FGFR3 was correlated with better DFS. |
| Databáze: | OpenAIRE |
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