A novel avalanche-confinement TEPC for microdosimetry at nanometric level
| Autor: | D. Bortot, V. Conte, Stefano Agosteo, Stefano Pasquato, P. Colautti, Alberto Fazzi, Andrea Pola, D. Mazzucconi |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Range (particle radiation)
Photon Materials science Radiation business.industry Physics QC1-999 Proportional counter Microdosimetry Particle detector 030218 nuclear medicine & medical imaging Nanodosimetry Tissue equivalent proportional counter (TEPC) Instrumentation 03 medical and health sciences Physics and Astronomy (all) Optics 0302 clinical medicine 030220 oncology & carcinogenesis Relative biological effectiveness Measuring instrument business Particle beam |
| Zdroj: | EPJ Web of Conferences, Vol 153, p 01011 (2017) |
| Popis: | The tissue equivalent proportional counter (TEPC) is the most accurate device for measuring the microdosimetric properties of a particle beam, showing to assess the relative biological effectiveness by linking the physical parameters of the radiation field with the corresponding biological response. Nevertheless, no detailed information on the track structure of the impinging particles can be obtained, since the lower operation limit of the common TEPCs is about 0.3 μm. On the other hand, the pattern of particle interactions at the nanometer level, which demonstrated to have a strong correlation with radiation-induced damages to the DNA, is measured directly by only three different nanodosimeters worldwide: practical instruments are not yet available. The gap between microdosimetry and track-nanodosimetry can be filled partially by extending the TEPC response down to the nanometric region. A feasibility study of a novel TEPC designed to simulate tissue-equivalent sites in the nanometric domain was performed. The present paper aims at describing the design, the development and the characterization of this avalanche-confinement TEPC. Irradiations with photons, fast neutrons and low-energy carbon ions demonstrated the capability of this TEPC of measuring in the range 0.3 μm–25 nm. |
| Databáze: | OpenAIRE |
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