Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction
| Autor: | John A. Corbett, Khalid S Hasan, Jack R. Lancaster, Ronald G. Tilton, Joseph R. Williamson, Yasuo Ido, Jin Lin Wang, Kathy Chang, Michael L. McDaniel, Michael A. Sweetland |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Blood Pressure Arginine Nitric Oxide Guanidines Nitric oxide Pathogenesis Islets of Langerhans chemistry.chemical_compound Diabetes mellitus Internal medicine Internal Medicine medicine Animals Insulin Insulinoma Cells Cultured omega-N-Methylarginine biology Vascular disease Rats Inbred Strains medicine.disease Pimagedine Rats Enzyme Activation Nitric oxide synthase Glucose Endocrinology chemistry Regional Blood Flow biology.protein Blood Vessels Omega-N-Methylarginine Amino Acid Oxidoreductases Nitric Oxide Synthase Diabetic Angiopathies Interleukin-1 |
| Zdroj: | Diabetes. 41:552-556 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/diab.41.4.552 |
| Popis: | Increased blood flow and vascular leakage of proteins preferentially affect tissues that are sites of diabetic complications in humans and animals. These vascular changes in diabetic rats are largely prevented by aminoguanidine. Glucose-induced vascular changes in nondiabetic rats are also prevented by aminoguanidine and by NG-monomethyl-L-arginine (NMMA), an established inhibitor of nitric oxide (NO.) formation from L-arginine. Aminoguanidine and NMMA are equipotent inhibitors of interleukin-1 beta-induced 1) nitrite formation (an oxidation product of NO.) and cGMP accumulation by the rat beta-cell insulinoma cell line RINm5F, and 2) inhibition of glucose-stimulated insulin secretion and formation of iron-nitrosyl complexes by islets of Langerhans. In contrast, NMMA is approximately 40 times more potent than aminoquanidine in elevating blood pressure in nondiabetic rats. These results demonstrate that aminoguanidine inhibits NO. production and suggest a role for NO. in the pathogenesis of diabetic vascular complications. |
| Databáze: | OpenAIRE |
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