Kallikrein 11 Down-regulation in Breast Carcinoma: Correlation With Prognostic Parameters
| Autor: | Sebnem Batur, Mete Bora Tuzuner, Oğuz Öztürk, Tülin Öztürk, Hulya Yilmaz-Aydogan, Turgay Isbir, Ayca Diren, Ecem Zeynep Kain |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Necrosis Lymphovascular invasion Proliferation Resistance Perineural invasion Down-Regulation Breast Neoplasms hK11 General Biochemistry Genetics and Molecular Biology breast cancer Messenger-Rna Breast cancer Internal medicine Kallikrein 11 medicine Biomarkers Tumor Humans Aged Pharmacology Cancer Survival business.industry Serine Endopeptidases Prostate Kallikrein medicine.disease Prognosis Expression Levels Gene Expression Regulation Neoplastic KLK11 Hormone receptor Female Kallikreins medicine.symptom Peptidases business Breast carcinoma Pathway Calcification Research Article |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 |
| Popis: | Background: Expression of kallikrein-11 (KLK11) has been found to be related to the prognosis of various human cancer types but its physiological functions in the steps of breast cancer (BC) progression are still unknown. Materials and Methods: BC and adjacent normal breast tissue samples were collected from 28 patients. KLK11 expression levels were determined by real-time polymerase chain reaction for each sample and associations with known prognostic features were statistically analyzed. Results: Although there was slight up-regulation in tumor tissues overall, significant down-regulation of KLK11 expression in tumor tissue was observed in the elderly and in patients with perineural invasion. Furthermore, tumor size, grade, mitotic score, necrosis, calcification, lymphatic invasion, hormone receptor status and Ki67 expression were associated with altered KLK11 level. Conclusion: Changes in expression levels of KLK11, associated with patient characteristics, might be used as complementary data in order to predict clinical outcome and prognosis in BC. Scientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [12974] The study was supported by a grant from the Scientific Research Projects Coordination Unit of Istanbul University (Project No: 12974). |
| Databáze: | OpenAIRE |
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