Anti-senescence compounds: A potential nutraceutical approach to healthy aging
| Autor: | Francesco Amenta, Felicia Gurău, E. Espinosa, Antonio Domenico Procopio, Francesco Prattichizzo, Massimiliano Bonafè, Fabiola Olivieri, Maria Cristina Albertini, Simone Baldoni |
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| Přispěvatelé: | Gurău, Felicia, Baldoni, Simone, Prattichizzo, Francesco, Espinosa, Emma, Amenta, Francesco, Procopio, Antonio Domenico, Albertini, Maria Cristina, Bonafè, Massimiliano, Olivieri, Fabiola |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Senescence Polyphenol Aging Antioxidant Mediterranean diet medicine.medical_treatment Anti-senescence diet Cellular senescence Polyphenols Senolytic Inflammation Biology Biochemistry Antioxidants Healthy Aging 03 medical and health sciences Nutraceutical medicine Humans Molecular Biology Cellular Senescence Reproducibility of Results 030104 developmental biology Neurology Immunology Dietary Supplements Life expectancy medicine.symptom Stem cell Diet Healthy Biotechnology |
| Popis: | The desire of eternal youth seems to be as old as mankind. However, the increasing life expectancy experienced by populations in developed countries also involves a significantly increased incidence of the most common age-related diseases (ARDs). Senescent cells (SCs) have been identified as culprits of organismal aging. Their number rises with age and their senescence-associated secretory phenotype fuels the chronic, pro-inflammatory systemic state (inflammaging) that characterizes aging, impairing the regenerative ability of stem cells and increasing the risk of developing ARDs. A variegated class of molecules, including synthetic senolytic compounds and natural compounds contained in food, have been suggested to possess anti-senescence activity. Senolytics are attracting growing interest, and their safety and reliability as anti-senescence drugs are being assessed in human clinical trials. Notably, since SCs spread inflammation at the systemic level through pro-oxidant and pro-inflammatory signals, foods rich in polyphenols, which exert antioxidant and anti-inflammatory actions, have the potential to be harnessed as "anti-senescence foods" in a nutraceutical approach to healthier aging. We discuss the beneficial effects of polyphenol-rich foods in relation to the Mediterranean diet and the dietary habits of long-lived individuals, and examine their ability to modulate bacterial genera in the gut. |
| Databáze: | OpenAIRE |
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