Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease

Autor:	Jiehua Wang, Han Zhang, Danxia Qin, Zhuquan Hong
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Male lcsh:Internal medicine lcsh:QH426-470 Disease Polymorphism Single Nucleotide Proinflammatory cytokine Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Gene Frequency Genetics Medicine Humans Genetic Predisposition to Disease Histamine H4 receptor Polymorphism Meniere’s disease lcsh:RC31-1245 Genetics (clinical) Meniere Disease Receptors Histamine H4 Histamine H4 receptors Proinflammatory cytokines business.industry Middle Aged medicine.disease Pathophysiology lcsh:Genetics 030104 developmental biology chemistry 030220 oncology & carcinogenesis Immunology Cytokines Female business Histamine Meniere's disease Research Article
Zdroj:	BMC Medical Genomics, Vol 12, Iss 1, Pp 1-7 (2019) BMC Medical Genomics
ISSN:	1755-8794
Popis:	Background The immune system is likely involved in the pathophysiology of Meniere’s disease (MD). However, its role of patients with MD has not been well studied. Given that histamine H4 receptors are highly expressed in immune system, we tested the hypothesis that histamine H4 receptor gene polymorphisms are a potential contributor to the risk of MD. Methods A group of patients was enrolled with a diagnosis of definite MD based on the American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium guidelines and a control group of patients without any vestibular disease. We selected one SNP, rs77485247 in HRH4 and conducted an exploratory investigation of its correlations with the symptoms of vertigo and proinflammatory cytokines levels in MD patients. Results HRH4 rs77485247 polymorphism may be associated with the risk of MD. Furthermore, basal levels of proinflammatory cytokines, such as IL-1β and TNF-α, in PBMCs are increased in patients with MD compared to control patients. This increased basal level of proinflammatory cytokines is prominent in MD patients with the A allele. Conclusions These suggested that HRH4 rs77485247 polymorphism may be an important mediator in regulating proinflammatory cytokines, which are involved in the pathogenesis of MD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3338c5cd7d23ea9ed8063df6a09dcafc http://link.springer.com/article/10.1186/s12920-019-0533-4 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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