Differential genetic regulation of canine hip dysplasia and osteoarthritis
| Autor: | Gang Guo, Shang-Zhong Xu, Lixin Du, William E. Hornbuckle, Nathan L. Dykes, Yachun Wang, Gregory M. Acland, Elizabeth Corey, Jody Sandler, Zhiwu Zhang, Nancy S. Moise, Steve G. Friedenberg, Wendy S. Vandenberg-Foels, Keyan Zhao, Ursula Krotscheck, George Lust, Lan Zhu, Xihui Sheng, Junya Li, Zhengkui Zhou, L.S. Hunter, Rory J. Todhunter |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Genetics and Genomics/Animal Genetics 040301 veterinary sciences Genetic Linkage Science Population Single-nucleotide polymorphism Genome-wide association study Quantitative trait locus Biology Genetics and Genomics/Complex Traits Hip dysplasia (canine) Polymorphism Single Nucleotide 0403 veterinary science 03 medical and health sciences Dogs Genetic linkage Internal medicine Osteoarthritis medicine Animals Dog Diseases education Genetics and Genomics/Genetics of Disease 030304 developmental biology Genetics Genetics and Genomics/Medical Genetics 0303 health sciences education.field_of_study Bone Diseases Developmental Multidisciplinary Chromosome Mapping 04 agricultural and veterinary sciences medicine.disease Genetics and Genomics/Disease Models Dysplasia Medicine Hip Joint Rottweiler Research Article |
| Zdroj: | PLoS ONE, Vol 5, Iss 10, p e13219 (2010) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BackgroundCanine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA.Methodology/principal findingsA total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at ∼22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with ∼3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with hip OA.Conclusion/significanceThe identified SNPs included those near known genes (PTPRD, PARD3B, and COL15A1) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and hip OA, which are common and debilitating conditions in both dogs and humans. |
| Databáze: | OpenAIRE |
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