Postimmunization Clearance of Liposome Entrapped Adenovirus Type 5 Hexon
| Autor: | Howard R. Six, Julius A. Kasel, William J. Kramp |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Injections
Intradermal Depot medicine.medical_treatment Pharmacology Injections Intramuscular General Biochemistry Genetics and Molecular Biology Adenoviridae Mice Viral Proteins Capsid Antigen medicine Animals Mice Inbred C3H Liposome Reactogenicity Chemistry Viral Vaccines Complete resolution Immunization Immunoglobulin G Liposomes Immunology Capsid Proteins Female Rabbits Adjuvant Clearance |
| Zdroj: | Experimental Biology and Medicine. 169:135-139 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | Clearance rates of 125I-hexon administered in three different forms from injection sites were assessed in animals. Aqueous and liposome-entrapped hexons following parental administration were cleared in linear fashion with half-lives that ranged from 1.5 to 4 and 30 to 45 hr, respectively. In contrast, hexons emulsified in complete Freund's adjuvant were cleared in a biphasic manner and tended to remain localized with 23 to 55% persisting after 16 days. No significant antigen accumulation in blood or any internal organs was detected following the three modes of immunization. These data suggest that formation of a transient antigen “depot” at injection sites may contribute to the adjuvant effect of liposomes but the complete resolution of this “depot” may avoid significant local reactogenicity. |
| Databáze: | OpenAIRE |
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