Role of brain neurotransmitters on neurotensin-induced gastric cytoprotection
| Autor: | Donald A. Stanley, Daniel E. Hernandez, Melvin Ja, Arthur J. Prange |
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| Rok vydání: | 1985 |
| Předmět: |
Agonist
Male Restraint Physical medicine.medical_specialty medicine.drug_class Clinical Biochemistry (+)-Naloxone Toxicology Biochemistry Injections Receptors Dopamine Behavioral Neuroscience chemistry.chemical_compound Internal medicine Muscarinic acetylcholine receptor Cisterna Magna Medicine Animals Humans Stomach Ulcer Biological Psychiatry Neurotensin Injections Intraventricular Pharmacology Brain Chemistry Neurotransmitter Agents business.industry Rats Inbred Strains Receptor antagonist Receptors GABA-A Cytoprotection Receptors Muscarinic Rats Cold Temperature Endocrinology chemistry Receptors Serotonin Receptors Opioid Haloperidol Serotonin business Acetylcholine Injections Intraperitoneal Stress Psychological medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 22(4) |
| ISSN: | 0091-3057 |
| Popis: | We have reported previously that intracisternal (IC) administration of neurotensin (NT) prevents stress-induced gastric ulcers in rats. This effect of NT appears to be mediated by the central nervous system because peripheral (IV) NT is totally ineffective. The present study sought to clarify the central mechanism of the cytoprotective effect of NT by utilizing pharmacological treatments which alter the function of brain neurotransmitter systems. Pretreatment with intracerebroventricular (ICV) administration of agonists and antagonists of acetylcholine (ACh), gamma-aminobutyric acid (GABA), and serotonin (5-HT) receptors or with an anti-opiate (naloxone) agent did not significantly alter NT-induced cytoprotection. However, pretreatment with ICV haloperidol, a dopamine (DA) receptor antagonist, totally blocked NT's cytoprotective effect. In addition, pretreatment with methylphenidate, a DA receptor agonist, produced cytoprotection similar to IC NT. These data indicate that NT-induced cytoprotection is not mediated by 5-HT, GABA, ACh (muscarinic) receptors, or endogenous opiate systems, but suggest interactions between brain DA systems and NT. |
| Databáze: | OpenAIRE |
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