The Rietveld method as a tool to quantify the amorphous amount of microcrystalline cellulose
| Autor: | Fabio Furlan Ferreira, Laysa Pires de Figueiredo |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Materials science
Solid-state Pharmaceutical Science Corundum engineering.material Amorphous solid Microcrystalline cellulose Excipients Crystallography chemistry.chemical_compound Crystallinity chemistry Chemical engineering X-Ray Diffraction Phase (matter) engineering Fourier transform infrared spectroscopy Powders Cellulose Crystallization Powder diffraction |
| Zdroj: | Journal of pharmaceutical sciences. 103(5) |
| ISSN: | 1520-6017 |
| Popis: | With the use of X-ray powder diffraction data and the Rietveld method, we verified that both microcrystalline cellulose PH-101 and PH-102 presented differences in the crystallinity degree. The results revealed these samples are semicrystalline in nature and via Rietveld refinements, it was possible, adding a known amount of an internal standard of corundum to the samples, to perform quantitative phase analyses, which allowed us to determine the amorphous amount of the studied samples: 63.7(11) wt % in microcrystalline cellulose PH-101 and 51.0(11) wt % in microcrystalline cellulose PH-102. An important contribution of this work refers to the attempt of using this simple method, permitting to evaluate the degree of crystallinity of microcrystalline cellulose. |
| Databáze: | OpenAIRE |
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