TP53 dysfunction in diffuse large B-cell lymphoma
| Autor: | Ken H. Young, Ting Xun Lu, Wei Xu, Jianyong Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell cycle checkpoint endocrine system diseases Somatic cell Apoptosis Biology 03 medical and health sciences stomatognathic system immune system diseases hemic and lymphatic diseases microRNA medicine Humans Gene Silencing neoplasms Inflammation Immunity Cellular Cell Cycle Autophagy Hematology Genes p53 medicine.disease Lymphoma Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Oncology Immunology Cancer research biology.protein Mdm2 Lymphoma Large B-Cell Diffuse Diffuse large B-cell lymphoma Signal Transduction |
| Zdroj: | Critical Reviews in Oncology/Hematology. 97:47-55 |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2015.08.006 |
| Popis: | The aberrations of TP53 gene and dysregulation of the TP53 pathway are important in the pathogenesis of many human cancers, including malignant lymphomas, especially for diffuse large B cell lymphoma (DLBCL). By regulating many downstream target genes or molecules, TP53 governs major defenses against tumor growth and promotes cellular DNA repair, apoptosis, autophagy, cell cycle arrest, signaling, transcription, immune or inflammatory responses and metabolism. Dysfunction of TP53, including microRNA regulations, copy number alterations of TP53 pathway and TP53 itself, dysregulation of TP53 regulators, and somatic mutations by abnormal TP53 function modes, play an important role in lymphoma generation, progression and invasion. The role of TP53 in DLBCL has been widely explored recently. In this review, we summarized recent advances on different mechanisms of TP53 in DLBCL and new therapeutic approaches to overcome TP53 inactivation. |
| Databáze: | OpenAIRE |
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