Efficacy of pulse steroid therapy in patients critically ill with COVID-19
| Autor: | B Demir, O Gundogdu, I Ersan, C O Coskun |
|---|---|
| Přispěvatelé: | Tıp Fakültesi |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Economics and Econometrics
medicine.drug_class Critical Illness medicine.medical_treatment Methylprednisolone Materials Chemistry Media Technology medicine Humans Intubation Dexamethasone Retrospective Studies SARS-CoV-2 business.industry Mortality rate COVID-19 Forestry Retrospective cohort study COVID-19 pulse steroid therapy thrombosis d-dimer corticosteroid medicine.disease Thrombosis Pneumonia Anesthesia Corticosteroid business medicine.drug |
| Popis: | OBJECTIVES: The aim of this study was to determine the efficacy of pulse steroid therapy administered to patients critically ill with COVID-19 progressing into severe pneumonia. METHODS: A total of 600 patients included in this retrospective study were divided into three groups. Group 1 (control group): 200 patients who did not receive steroid treatment, Group 2: 200 patients who received dexamethasone 1x8 milligram (mg) or methylprednisolone 1x80 mg, Group 3: (pulse steroid therapy group): 200 patients who received 1 g methylprednisolone followed by 1x80 mg methylprednisolone. Demographic and laboratory data were recorded. RESULTS: Mortality rates in groups 1, 2 and 3 were 77 %, 53.55 %, and 58.5 %, respectively. The ratios of intubated patients in groups 1, 2 and 3 were 70 %, 45.5 % and 56 %, respectively. The numbers of patients whose Ddimer values were above 2,250 ng/mL (cut-off value for D-dimer in this study) in groups 2, 1 and 3 were 65, 107, and 105, respectively. CONCLUSION: Pulse steroid therapy does not shorten the duration of hospital stay, does not reduce the need for intubation and increases the risk of thrombosis by significantly increasing the level of D-dimer among patients critically and severely ill with COVID-19 (Tab. 4, Fig. 3, Ref. 20) Keywords: COVID-19, pulse steroid therapy, thrombosis, d-dimer, corticosteroid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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