Intracerebral transfection of anti-rabies virus antibodies is an effective therapy for rabies
| Autor: | Washington C. Agostinho, Paulo Eduardo Brandão |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Neurology Fatal outcome Disease Antibodies Viral medicine.disease_cause Group A Mice Drug Delivery Systems 0302 clinical medicine biology Vaccination Brain Transfection medicine.anatomical_structure Female Antibody Fluorescein-5-isothiocyanate medicine.medical_specialty Rabies Central nervous system Virus Incubation period Immunoglobulin Fab Fragments 03 medical and health sciences Cellular and Molecular Neuroscience Drug treatment Virology medicine Animals Humans Fluorescent Dyes Injections Intraventricular COBAIAS business.industry Rabies virus medicine.disease Survival Analysis Disease Models Animal 030104 developmental biology Rabies Vaccines biology.protein Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1538-2443 1355-0284 |
| DOI: | 10.1007/s13365-020-00883-8 |
| Popis: | Rabies is a zoonotic neurological disease with 100% lethality. Some of the rare human patients who survived after multiple drug treatment have inherited severe sequelae. The objective of this study was to investigate the action of the transfection of antibodies against rabies in the central nervous system of mice as target therapy for rabies.Author summaryThe present study showed that after 48 h of RABV inoculation, mice injected by the intracerebral route with anti-RABV F(ab’)2 complexed with Bioporter® Protein Delivery Reagent (Genlantis) as a transfection agent, showing a morbidity/mortality rate of 30% with a minimum incubation period of seven days, while in the control group a significantly higher (p |
| Databáze: | OpenAIRE |
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