Standardized Procedural Practices of the Ontario Prenatal Screening Program for aneuploidies and open neural tube defects
| Autor: | Kika Veljkovic, Alan Dennis, Ayeshah Chaudhry, Shamim Rashid, Nathalie Lepage, Julie L.V. Shaw, Sandra A. Farrell, Danijela Konforte |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pediatrics
medicine.medical_specialty Down syndrome Standardization Clinical Biochemistry Nuchal translucency Second trimester Pregnancy Prenatal Diagnosis Medicine Humans Medical physics Neural Tube Defects Demography Ultrasonography Ontario Modalities business.industry General Medicine medicine.disease Aneuploidy First trimester Prenatal screening Health Records Personal Female Population screening Down Syndrome business |
| Zdroj: | Clinical biochemistry. 45(15) |
| ISSN: | 1873-2933 |
| Popis: | Background/Objectives The Ontario Prenatal Screening Program (OPSP) follows internationally recognized standardized procedures for laboratories and genetics clinics. However, it has been found that some procedures are subject to interpretation, so the current procedures are designed to facilitate a unified approach in the interpretation of literature recommendations. In Ontario, the OPSP offers multiple screening modalities with integrated prenatal screening (including both first and second trimester markers) being the most commonly chosen option. Other screening modalities include first trimester screening, second trimester quad screening, serum integrated screening, and NT-Quad. Methods The standardization was based on a literature review and on current practices in Ontario. Results/discussion The main finding of the review was a paucity of published data relating to the procedures and the decision-making processes involved in prenatal screening. The purpose of this publication is to provide the most up-to-date and pertinent information for clinical laboratory professionals involved with prenatal screening for Down syndrome, trisomy 18 and open neural tube defects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect