Circulating Adiponectin in Preterm Infants Fed Long-Chain Polyunsaturated Fatty Acids (LCPUFA)-Supplemented Formula—A Randomized Controlled Study
| Autor: | Emanouil Karavitakis, Helen Mandyla, Alexandra Margeli, Christina Lazaropoulou, Tania Siahanidou, Ioannis Papassotiriou |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty law.invention Randomized controlled trial Risk Factors law Internal medicine medicine Humans Longitudinal Studies Triglycerides Metabolic Syndrome chemistry.chemical_classification Adiponectin business.industry Cholesterol HDL Infant Newborn Infant Formula Endocrinology chemistry Dietary Supplements Pediatrics Perinatology and Child Health Fatty Acids Unsaturated Female business Long chain Infant Premature Polyunsaturated fatty acid |
| Zdroj: | Pediatric Research. 63:428-432 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/pdr.0b013e31816780e4 |
| Popis: | Adiponectin has potent insulin-sensitizing effects, improves lipid metabolism, and potentially protects against the development of metabolic syndrome. Thus, increasing adiponectin levels in preterm infants at risk for developing metabolic syndrome may be of special interest. The aim of this study was to examine the effects of dietary long-chain polyunsaturated fatty acids (LCPUFA) on serum adiponectin and lipid concentrations in preterm infants. Adiponectin and lipid levels of 60 healthy preterm infants [gestational age 32.7 (1.9) wk] randomly assigned to be fed either 1) a formula containing LCPUFA [arachidonic and docosahexanoic] (+LCPUFA group) or 2) the same formula without LCPUFA (-LCPUFA/control group), were determined at mean (SD) 33.8 (11.7) d. Adiponectin and HDL-C concentrations were significantly higher in the +LCPUFA group than in controls (p = 0.002 and p = 0.01, respectively); whereas, triglyceride levels were lower (p = 0.06). Adiponectin correlated positively with HDL-C levels and negatively with triglyceride levels in the +LCPUFA group but not in the controls. In conclusion, circulating adiponectin concentrations were higher in preterm infants fed a formula containing LCPUFA than infants fed an LCPUFA-free formula and they correlated with lipidemic profile. |
| Databáze: | OpenAIRE |
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