Determinants of survival in myelofibrosis patients undergoing allogeneic hematopoietic cell transplantation
| Autor: | Ibrahim Yakoub-Agha, Martin Bornhäuser, Nienke Zinger, Jaime Sanz, Jakob Passweg, Simona Iacobelli, Patrick Hayden, Riitta Niittyvuopio, Juan Carlos Hernández-Boluda, Peter Dreger, Emanuele Angelucci, Nicolaus Kröger, Jan J. Cornelissen, Antonin Vitek, Arturo Pereira, Tomasz Czerw, Tsila Zuckerman, Dietrich W. Beelen, Marie Robin, Eefke Petersen, Igor Wolfgang Blau, Donal McLornan, Jürgen Finke, Lothar Kanz |
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| Přispěvatelé: | Hematology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_specialty Congenital cytomegalovirus infection Medizin Graft vs Host Disease Disease Kaplan-Meier Estimate 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Recurrence Internal medicine Medicine Humans Transplantation Homologous Registries Sibling Myelofibrosis Proportional Hazards Models Retrospective Studies business.industry Incidence (epidemiology) Hematopoietic Stem Cell Transplantation Retrospective cohort study Hematology medicine.disease Prognosis Transplantation Europe Settore MED/01 030104 developmental biology Treatment Outcome surgical procedures operative Oncology Primary Myelofibrosis 030220 oncology & carcinogenesis Female business Serostatus |
| Zdroj: | LEUKEMIA r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname Leukemia, 35(1), 215-224. Nature Publishing Group Leukemia r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe |
| ISSN: | 0887-6924 |
| Popis: | We aimed to evaluate the determinants of survival in myelofibrosis patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) and to describe factors predicting the main post-HCT complications. This retrospective study by the European Society for Blood and Marrow Transplantation included 2916 myelofibrosis patients who underwent first allo-HCT from an HLA-identical sibling or unrelated donor between 2000 and 2016. After a median follow-up of 4.7 years from transplant, projected median survival of the series was 5.3 years. Factors independently associated with increased mortality were age ≥ 60 years and Karnofsky Performance Status |
| Databáze: | OpenAIRE |
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