A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc
| Autor: | Zhenzhen Wang, Yongbo Xue, Kongchao Wang, Yu Zhang, Zengwei Luo, Junjun Liu, Linzhen Hu, Jinwen Zhang, Yonghui Zhang, Kaiping Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Zanthoxylum Stereochemistry Kaposi’s sarcoma associated herpes virus Phytochemicals Pharmaceutical Science 01 natural sciences Article Analytical Chemistry lcsh:QD241-441 03 medical and health sciences Herpes virus lcsh:Organic chemistry Glucosides Stomach ache Drug Discovery Humans Physical and Theoretical Chemistry Sarcoma Kaposi zanthoxylum schinifolium megastigmane sesquiterpenoid Folk medicine Traditional medicine biology Molecular Structure 010405 organic chemistry Cyclohexanones Plant Extracts Circular Dichroism Organic Chemistry Absolute configuration biology.organism_classification 0104 chemical sciences 030104 developmental biology Rutaceae Phytochemical Chemistry (miscellaneous) Herpesvirus 8 Human Molecular Medicine Norisoprenoids Zanthoxylum schinifolium |
| Zdroj: | Molecules Molecules, Vol 21, Iss 3, p 383 (2016) Molecules; Volume 21; Issue 3; Pages: 383 |
| ISSN: | 1420-3049 |
| Popis: | Zanthoxylum schinifolium Sieb. et Zucc. (Rutaceae), a dioecious shrub with hooked prickly branches, has been used as folk medicine for the treatment of the common cold, stomach ache, diarrhea, and jaundice in China, Korea, and Japan. In our phytochemical investigations on this genus, a new megastigmane sesquiterpenoid, which is referred to as schinifolenol A (1), was isolated from Z. schinifolium. The stereochemistry was characterized via the analyses of extensive spectra. The absolute configuration was established by the application of a modified Mosher’s experiment and assisted by a time-dependent density functional theory (TD-DFT) on calculated electronic circular dichroism (ECD). Bioactivity screenings showed that compound 1 exhibited a safe hypotoxicity and a better selectivity on anti-Kaposi’s sarcoma associated herpes virus (KSHV). |
| Databáze: | OpenAIRE |
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