NK-cell repertoire is feasible for diagnosing Epstein-Barr virus-infected NK-cell lymphoproliferative disease and evaluating the treatment effect
| Autor: | Yasufumi Takeshita, Ji Yoo Kim, Emiko Sato, Shigenori Kusuki, Maho Koyama, Naoki Sakata, Akifumi Sakata, Keisei Kawa, Takayuki Okamura, Masami Inoue, Banryoku Higuchi, Akihisa Sawada, Masahiro Yasui |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Epstein-Barr Virus Infections Adolescent Biology medicine.disease_cause Herpesviridae Natural killer cell Chronic active EBV infection Recurrence hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine Humans Transplantation Homologous Child Infant Hematology medicine.disease Epstein–Barr virus Lymphoproliferative Disorders Transplantation Killer Cells Natural Leukemia medicine.anatomical_structure Treatment Outcome Child Preschool Monoclonal Immunology Disease Progression Hydroa vacciniforme Drug Evaluation Female Biomarkers Stem Cell Transplantation |
| Zdroj: | American journal of hematology. 81(8) |
| ISSN: | 0361-8609 |
| Popis: | Epstein-Barr virus (EBV) occasionally infects T and NK cells and causes EBV-infected T/NK-cell lymphoproliferative disease (LPD), which comprises chronic active EBV infection, EBV-associated hemophagocytic syndrome, mosquito allergy, hydroa vacciniforme, aggressive NK-cell leukemia, and NK/T-cell lymphoma. The diagnosis is proven by the monoclonal proliferation of EBV-infected T or NK cells, which is a time-consuming and complicated method. T-cell monoclonality is helpful for the screening of EBV-infected T-cell LPD in patients with EBV-genome burden and is easily shown with T-cell-receptor rearrangement or the T-cell repertoire, whereas NK-cell monoclonality is difficult to prove due to its lacking such rearranged receptors. We investigated a set of killer immunoglobulin-like receptors (KIRs) and also CD94-NKG2 heterodimers on NK cells, namely the NK-cell repertoire. Skewed repertoires were seen in all patients with EBV-infected NK-cell LPD, but not in any patients with EBV-infected T-cell LPD and were restored only after successful treatment. The normal KIR repertoire is variable for each individual and it seems difficult to detect minimal residual EBV-infected lymphocytes. However, the NK-cell repertoire is feasible for identifying EBV-infected NK-cell LPD and evaluating the treatment effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text