Is nuclear sirtuin SIRT6 a master regulator of immune function?
| Autor: | Mahesh P. Gupta, Vinodkumar B. Pillai |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
SIRT6 medicine.medical_specialty Cell signaling Physiology Endocrinology Diabetes and Metabolism Review Biology 03 medical and health sciences 0302 clinical medicine Immune system Physiology (medical) Internal medicine medicine Animals Humans Sirtuins Cell Nucleus Glutaminolysis Effector Warburg effect Cell biology 030104 developmental biology Cell metabolism Endocrinology Immune System 030220 oncology & carcinogenesis Sirtuin biology.protein Energy Metabolism Metabolic Networks and Pathways |
| Zdroj: | Am J Physiol Endocrinol Metab |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.00483.2020 |
| Popis: | The ability to ward off pathogens with minimal damage to the host determines the immune system's robustness. Multiple factors, including pathogen processing, identification, secretion of mediator and effector molecules, and immune cell proliferation and differentiation into various subsets, constitute the success of mounting an effective immune response. Cellular metabolism controls all of these intricate processes. Cells utilize diverse fuel sources and switch back and forth between different metabolic pathways depending on their energy needs. The three most critical metabolic pathways on which immune cells depend to meet their energy needs are oxidative metabolism, glycolysis, and glutaminolysis. Dynamic switching between these metabolic pathways is needed for optimal function of the immune cells. Moreover, switching between these metabolic pathways needs to be tightly regulated to achieve the best results. Immune cells depend on the Warburg effect for their growth, proliferation, secretory, and effector functions. Here, we hypothesize that the sirtuin, SIRT6, could be a negative regulator of the Warburg effect. We also postulate that SIRT6 could act as a master regulator of immune cell metabolism and function by regulating critical signaling pathways. |
| Databáze: | OpenAIRE |
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