The new immunosuppression: intervention at the dendritic cell-T-cell interface
| Autor: | Kathleen F. Nolan, Stephen F. Yates, Herman Waldmann, Alison M. Paterson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Graft Rejection
Immunosuppression Therapy medicine.medical_specialty T-Lymphocytes Endocrinology Diabetes and Metabolism medicine.medical_treatment T cell Antibodies Monoclonal Immunosuppression Context (language use) Dendritic Cells Dendritic cell Biology Organ transplantation Immune tolerance Immunological synapse medicine.anatomical_structure Immunity Immunology Immune Tolerance medicine Animals Humans Immunology and Allergy Immunosuppressive Agents |
| Popis: | Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a 'tolerogenic context'. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function. |
| Databáze: | OpenAIRE |
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