PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

Autor: Evangelina Avila-Muñoz, Clorinda Arias, Manuel Flores-León, Nelly Rodríguez-Corona, Karina Sánchez-Alegría
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Central nervous system
Review
Biology
Synaptic Transmission
Catalysis
Epigenesis
Genetic
neuroinflammation
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
Phosphatidylinositol 3-Kinases
Gene expression
medicine
Transcriptional regulation
Autophagy
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
PI3K/AKT/mTOR pathway
Tissue homeostasis
Neuroinflammation
PI3K signaling
Inflammation
Neurons
Organic Chemistry
Neurodegeneration
neurodegeneration
Neurodegenerative Diseases
General Medicine
medicine.disease
neuronal metabolism
Computer Science Applications
030104 developmental biology
medicine.anatomical_structure
Gene Expression Regulation
lcsh:Biology (General)
lcsh:QD1-999
gene expression
Neuroscience
Proto-Oncogene Proteins c-akt
Function (biology)
Signal Transduction
Zdroj: International Journal of Molecular Sciences, Vol 19, Iss 12, p 3725 (2018)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. Less is known regarding its critical role in neuronal physiology, neuronal metabolism, tissue homeostasis, and the control of gene expression in the central nervous system in healthy and diseased states. The aim of the present work is to review cumulative evidence regarding the participation of PI3K pathways in neuronal function, focusing on their role in neuronal metabolism and transcriptional regulation of genes involved in neuronal maintenance and plasticity or on the expression of pathological hallmarks associated with neurodegeneration.
Databáze: OpenAIRE
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