Disrupting stromal barriers to enhance photothermal-chemo therapy using a halofuginone-loaded Janus mesoporous nanoplatform
| Autor: | Xiaodan Su, Zhaogang Teng, Jun Tao, Wei Lu, Xiaojun Zhang, Yuxia Tang, Meng Dang, Rui Tang, Wenhui Shi, Ruifa Yu |
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| Rok vydání: | 2022 |
| Předmět: |
Drug
Stromal cell Photothermal Therapy media_common.quotation_subject Biomaterials Mice Drug Delivery Systems Colloid and Surface Chemistry Piperidines In vivo Cell Line Tumor medicine Animals Humans Quinazolinones media_common Mice Inbred BALB C Halofuginone Chemistry Therapeutic effect Hyperthermia Induced Phototherapy Photothermal therapy In vitro Surfaces Coatings and Films Electronic Optical and Magnetic Materials Doxorubicin Drug delivery Cancer research Nanoparticles medicine.drug |
| Zdroj: | Journal of Colloid and Interface Science. 610:313-320 |
| ISSN: | 0021-9797 |
| Popis: | Dense tumor stroma is the physiological barrier in drug delivery that prevents anticancer drugs from entering the tumor, thereby seriously limiting the drugs' therapeutic effect. In this study, a Janus nanoplatform consisting of periodic mesoporous organosilica-coated platinum nanoplatforms (JPMO-Pt) and anti-stroma drug halofuginone (HF) (denoted as JPMO-Pt-HF), was developed to deplete the tumor stroma and synergistically treat breast cancer in BALB/c mice. The prepared JPMO-Pt had a uniform size of 245 nm, a good dispersion, an excellent in vitro and in vivo biocompatibility, and a high loading capacity for HF (up to 50 μg/mg). The antitumor experiments showed that the survival rate of 4T1 cells exhibited an obvious downward trend when the cells were incubated with the JPMO-Pt-HF and irradiated with 808 nm laser. Moreover, the cell survival rate was only about 10% at 48 h when the HF concentration was 2.0 μg/mL. Notably, JPMO-Pt-HF under irradiation had an excellent synergistic therapeutic effect on tumor cells. In vivo antitumor experiment further showed that the JPMO-Pt-HF, in combination with laser irradiation, could minimize tumor growth, showing significantly better effects than those observed for the case of monotherapy involving photothermal therapy (PTT) (152 vs. 670 mm3, p |
| Databáze: | OpenAIRE |
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