Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty
| Autor: | Ismail Oran, Goksel Gokce, Zeki Topcu, Zeliha Kerry, Gonen Ozsarlak-Sozer |
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| Rok vydání: | 2010 |
| Předmět: |
Taurine
medicine.medical_specialty Intimal hyperplasia Vascular smooth muscle Physiology medicine.medical_treatment Myocytes Smooth Muscle medicine.disease_cause Biochemistry Muscle Smooth Vascular chemistry.chemical_compound Internal medicine Angioplasty medicine Animals Myocyte Buthionine sulfoximine Buthionine Sulfoximine Cell Proliferation Glutathione Peroxidase Hyperplasia Glutathione Disulfide Arteries General Medicine Anatomy Telomere Vascular System Injuries Atherosclerosis medicine.disease Glutathione Oxidative Stress Endocrinology chemistry Rabbits Tunica Intima Angioplasty Balloon Oxidative stress |
| Zdroj: | Journal of Physiology and Biochemistry. 67:35-42 |
| ISSN: | 1877-8755 1138-7548 |
| DOI: | 10.1007/s13105-010-0046-2 |
| Popis: | Telomeres are specialized DNA-protein complexes found at the tips of linear chromosomes. In this study, we investigated the effects of oxidative stress on telomeric length distribution of proliferating vascular smooth muscle cells following balloon injury in single or combined treatment of rabbits with either buthionine sulfoximine or taurine. Exposure to oxidative stress increased the balloon injury whereas taurine treatment significantly diminished l-buthionine-sulfoximine-related intimal hyperplasia. Our results also showed that both variables had a significant influence on mean telomeric length distribution. |
| Databáze: | OpenAIRE |
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