CHRONIC CAFFEINE'S EFFECTS ON BEHAVIOURAL CHANGES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
| Autor: | Carmen-Denise-Mihaela Zahiu, Leon Zagrean, Calin Petru Tataru, Bădescu Sv, Ana-Maria Zagrean, Georgescu El, L. Kobylinska |
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| Rok vydání: | 2019 |
| Předmět: |
Elevated plus maze
medicine.medical_specialty Endocrine and Autonomic Systems business.industry medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Intraperitoneal injection Streptozotocin medicine.disease Anxiolytic chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus medicine Anxiety medicine.symptom business Caffeine General Endocrinology Behavioural despair test medicine.drug |
| Zdroj: | Acta endocrinologica (Bucharest, Romania : 2005). 12(3) |
| ISSN: | 1841-0987 |
| Popis: | CONTEXT: Memory deficits, anxiety and depression are often associated with diabetes, worsening diabetic patients’ prognosis. Caffeine, a worldwide used psychoactive substance, is a candidate for improving these conditions. OBJECTIVE: The aim of this study was to assess the behaviour in streptozotocin-induced diabetic Wistar rats and to evaluate the behavioural effects of caffeine administration. MATERIALS AND METHODS: Diabetes was induced by a single intraperitoneal injection of 50 mg/kg BW streptozotocin (n=10), while control rats received the vehicle (n=9). After six weeks, behavioural tests for anxiety, memory and depression were performed: elevated plus maze (EPM) test, novel object recognition (NOR) test and forced swimming test (FST), respectively. The tests were repeated after further 2 weeks of continuous caffeine administration (20 mg/kg BW/day in drinking water). RESULTS: Diabetic rats manifested a high anxiety level, showed by a reduced exploratory activity compared to control rats (p |
| Databáze: | OpenAIRE |
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