Human Sialic acid O-acetyl esterase (SIAE) – mediated changes in sensitivity to etoposide in a medulloblastoma cell line
| Autor: | Mather, Rebecca L., Loveson, Katie F., Fillmore, Helen L. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell biology medicine.medical_treatment lcsh:Medicine APC-PAID Biology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Acetyltransferases Cell Line Tumor Gangliosides medicine Humans lcsh:Science Child Etoposide Cancer Membrane Potential Mitochondrial Medulloblastoma Chemotherapy Multidisciplinary Ganglioside Brain Neoplasms lcsh:R Biomedical Sciences Acetylation medicine.disease Clone Cells Sialic acid 030104 developmental biology chemistry Apoptosis Cell culture Cancer research lcsh:Q Acetylesterase lipids (amino acids peptides and proteins) 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Mather, R L, Loveson, K & Fillmore, H 2019, ' Human Sialic acid O-acetyl esterase (SIAE) – mediated changes in sensitivity to etoposide in a medulloblastoma cell line ', Scientific Reports, vol. 9, 8609 . https://doi.org/10.1038/s41598-019-44950-5 Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-44950-5 |
| Popis: | Medulloblastoma (MB), the most common malignant paediatric brain tumour occurs in the cerebellum. Advances in molecular genomics have led to the identification of defined subgroups which are associated with distinct clinical prognoses. Despite this classification, standard therapies for all subgroups often leave children with life-long neurological deficits. New therapeutic approaches are therefore urgently needed to reduce current treatment toxicity and increase survival for patients. GD3 is a well-studied ganglioside which is known to have roles in the development of the cerebellum. Post-partum GD3 is not highly expressed in the brain. In some cancers however GD3 is highly expressed. In MB cells GD3 is largely acetylated to GD3A. GD3 is pro-apoptotic but GD3A can protect cells from apoptosis. Presence of these gangliosides has previously been shown to correlate with resistance to chemotherapy. Here we show that the GD3 acetylation pathway is dysregulated in MB and as a proof-of-principle we show that increased GD3 expression sensitises an MB cell line to etoposide. |
| Databáze: | OpenAIRE |
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